Tunable Leuko-polymersomes That Adhere Specifically to Inflammatory Markers
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چکیده
منابع مشابه
Tunable leuko-polymersomes that adhere specifically to inflammatory markers.
The polymersome, a fully synthetic cell mimetic, is a tunable platform for drug delivery vehicles to detect and treat disease (theranostics). Here, we design a leuko-polymersome, a polymersome with the adhesive properties of leukocytes, which can effectively bind to inflammatory sites under flow. We hypothesize that optimal leukocyte adhesion can be recreated with ligands that mimic receptors o...
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Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason--along with others reviewed here--comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly appropriate. We summarize the wide range of polym...
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ژورنال
عنوان ژورنال: Langmuir
سال: 2010
ISSN: 0743-7463,1520-5827
DOI: 10.1021/la1017032